Mesothelioma: know and understand it can assign
Bad mesoteliomas are neoplastico growth of mesothelial cells in the body. Mesothelial cells are found in the lining of different body cavities. To appoint the pleura, which is peritoneal, pericardium, and testis are lined by these cells. The poor majority of mesotelioma occurs in the pleura, explaining almost 90% of all cases. United States, the incidence of bad mesotelioma is locked in 0.1-0.2 in 100,000 which is higher than the incidence of International 0.9 per 100,000 for both sexes. Two tenfold increase in risk is seen among people who are exposed to asbestos. 2500 to 3000 cases are diagnosed each year around the country.
The peak incidence of the disease occurs in the 3ro and 4TA decade of life, with two thirds of cases coming in and 5tas 6tas decades. The bad mesotelioma is more commonly - seen among men with a male female ratio at 3:1. Among men, 53% have disclosed exposure to asbestos professional. The descriptions of the functions most commonly cited as possible the explosives were workers, naval mechanics, construction workers, miners, mechanics and motor vehicles including bakers. 46% of men disclosed about exposure to asbestos previous unprofessional. Among women, 75% were released for previous exposure to asbestos, half of which was the secondary contact of the house. Epithelioid was the histologic subtype most commonly found among women, and has mesotelioma commonly affected as much as possible to the pleura.
Epithelioid, and sarcomatoso biphasic (mixed) is the three major histologic subtypes of bad mesotelioma. Sixty to seventy (60-70%) of epithelioid mesotelioma is. These transformed cells begin as nodules and plaques individual who then come together to form then leaves. The plates start to the portions smaller than the chest and move slowly up to steal in the upper chest and interlobulares slots. The growth of the tumor, in most cases also encajona diaphragm, chest tube drainage and different areas. If he is lazy untreated, the disease can rapidly invade parenquimia lung, esophagus, and can reach including the great vessels of the heart and the surrounding bony structures such as walls, ribs and vertebrae of the chest . Exposure to asbestos is the main trigger is commonly cited in the wrong patogenesia mesotelioma. Various forms of asbestos, as chrysotile, amphibole, erionite, crocidolite, amosite and all are cited for causing the formation of more than 80% of mesoteliomas. Of crocidolite Asbestos is commonly the cause for mesoteliomas found among miners, manufacturers of asbestos, and construction workers from the heat.
Amphiboles are found to be more carcinogenic than its counterparts of chrysotile. Exposure to radiation by using what is silicatos dioxide as the zeolite and thorium was also linked to the wrong patogenesia mesotelioma. It even date with all the controversy, Simian virus 40, he was also bothered to have a role in the formation of etiológico mesotelioma. Cromosómicos change him more frequently found in poor mesotelioma include a loss of one copy of chromosome 22, alterations in p16 (CDKN2A) and p14 (ARF) of the gene of the tumor supresor and a functional loss of Neurofibromin 2 (NF2). Interleukin 8 has also been shown to have a direct effect on the growth potential of mesothelial cells and thus contributes to the continued growth of mesothelial cells bad. Essentially, it continues to be exposure to asbestos which is instigador be more common than bad patogenesia mesotelioma. Exposure to asbestos itself was also annoyed to cause the majority of mesoteliomas
Category Article Mesothelioma
